Almost as soon as researchers started exploring the capabilities of the CRISPR/Cas9 system, they recognized its potential use in targeted gene editing. But the intervening decades have seen slow progress as people worked to determine how to do so in a way that would be safe for use in humans. It was only a little over two years ago, decades after CRISPR's discovery, that the FDA approved the first CRISPR-based therapy , for sickle-cell anemia.

Now, following up on that success, a large Chinese collaboration has followed up with a description of an improved gene editing system that produces more focused changes and fewer mistakes. And they've used it to produce a therapy that addresses a disease that's closely related to sickle-cell anemia: β-Thalassaemia.

Gene editing and its limits

The CRISPR/Cas-9 system provides bacteria with a form of immunity. It uses specially structured RNAs (called guide RNAs) that can base-pair with a targeted sequence. The Cas-9 protein then recognizes this structure and cuts the DNA nearby. This is quite effective when the guide RNA can base-pair with a DNA virus, as the resulting cut will inactivate the virus.

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Amid customer dissatisfaction around Broadcom's VMware takeover, rivals have been trying to lure customers from the leading virtualization firm. One of VMware's biggest competitors, Nutanix, claims to have swiped tens of thousands of VMware customers.

Speaking at a press briefing at Nutanix’s .NEXT conference in Chicago this week, Nutanix CEO Rajiv Ramaswami said that “about 30,000 customers” have migrated from VMware to the rival platform, pointing to customer disapproval over Broadcom’s VMware strategy, SDxCentral , a London-based IT publication, reported today.

“I think there's no doubt that the customer sentiment continues to be negative about Broadcom,” Ramaswami said, per SDxCentral.

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In the 1970s, the late Jane Goodall observed a community of chimpanzees in Gombe, Tanzania, breaking into two factions; the males in one group ended up killing all the males in the rival group over the next four years, along with one female chimp. But the case was considered an anomaly, although there is genetic evidence suggesting this kind of split is a rare event occurring every 500 years or so. Now researchers have observed the largest known community of Ngogo chimpanzees in Uganda also permanently splitting into two rival groups with a similar outbreak of violence, according to a new paper published in the journal Science.

"What's especially striking is that the chimpanzees are killing former group members," said co-author Aaron Sandel , an anthropologist at the University of Texas, Austin. "The new group identities are overriding cooperative relationships that had existed for years. I would caution against anyone calling this a civil war. But the polarization and collective violence that we have observed with these chimpanzees may give us insight into our own species."

The authors analyzed 24 years' worth of data from social networks, 10 years of GPS tracking, and 30 years of demographic data on the Ngogo chimps in Uganda's Kibale National Park. They identified three distinct phases to the split. First there was an abrupt shift as chimp relationships became polarized into two distinct clusters: Western and Central. The chimps then spent the next two years increasingly avoiding those in their rival cluster; there were very few interactions across clusters, and Western male chimps started patrolling their territory, showing increased aggression toward Central males. By 2018, the fissure had become permanent.

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On the home stretch of their nine-day mission, the four astronauts flying aboard NASA's Orion spacecraft are just beginning to reflect on their experience of flying beyond the Moon.

Their memories of Monday's encounter with the Moon are still fresh as they return to Earth, heading for reentry and splashdown in the Pacific Ocean on Friday evening.

"I'm actually getting chills right now just thinking about it. My palms are sweating," said Reid Wiseman, commander of the Artemis II mission. "But it is amazing to watch your home planet disappear behind the Moon. You can see the atmosphere. You could actually see the terrain on the Moon projected across the Earth as the Earth was eclipsing behind the Moon. It was just an unbelievable sight, and then it was gone. It was out of sight."

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A federal appeals court refused to halt the Trump administration's efforts to blacklist Anthropic yesterday, denying the company's emergency motion for a stay. But the court granted the US-based AI firm's request to expedite the case and will hold oral arguments on May 19.

The ruling by the US Court of Appeals for the District of Columbia Circuit was issued by a panel of three judges appointed by Republicans, including Trump appointees Gregory Katsas and Neomi Rao. Katsas previously served as deputy counsel to the president during Trump's first term, while Rao served in the Trump administration's Office of Management and Budget. The judges' decision is a setback for Anthropic, but it's only one of two cases it filed against the Trump administration, and the AI firm has had more success in the other one.

Anthropic says it exercised its First Amendment rights by refusing to let Claude AI models be used for autonomous warfare and mass surveillance of Americans, and that Trump and Defense Secretary Pete Hegseth blacklisted it in retaliation. Trump directed all federal agencies to stop using Anthropic technology, and Hegseth labeled Anthropic a "Supply-Chain Risk to National Security," prohibiting military contractors from doing business with Anthropic.

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Among the requirements of Volkswagen's Dieselgate settlement with the Department of Justice back in 2016 was to start building electric vehicles locally at the company's factory in Chattanooga, Tennessee. That was a reality by 2021, when we drove our first US-made VW ID.4 . Five years later, VW is moving on. After mid-April, no more ID.4s will roll down Chattanooga's assembly line, which instead will be reconfigured for the brand's newly revealed gasoline-powered Atlas SUV.

The ID.4 was well-received when it debuted in 2021, and the model had a mostly strong 2025, selling 31 percent more than the year before. But sales of the electric VW collapsed after the Trump administration abolished the clean vehicle tax credit at the end of Q3 2025; the next three months saw ID.4 sales fall by 62 percent year over year.

VW is gambling that Americans will instead want more gas-powered SUVs—probably a decision made before Trump started a war in the Middle East that has increased the price of gasoline by more than a dollar per gallon in the last few weeks. Snark aside, the Atlas is VW's second-best seller here, and VW wants the second-gen Atlas in dealerships by this fall.

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A corporal in the Pennsylvania state police yesterday pleaded guilty to a mind-boggling set of crimes that include going through his co-workers' underwear, possessing a stolen gun, having child sexual abuse material on his hard drives, and using AI tools to create over 3,000 pornographic "deepfakes."

One of the deepfakes involved a district court judge, while many of the others were created based on photos downloaded illicitly from state databases, including driver's license photos.

Some of the imagery was even created at police barracks, using state-owned devices.

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An Ohio man became the first person convicted under the Take It Down Act after pleading guilty to creating and sharing both real and AI-generated explicit images of at least 10 victims without their consent.

According to a Justice Department press release , 37-year-old James Strahler II used AI tools to create fake sexualized images to harass at least six women he knew. In some images, he depicted one victim engaged in sex with her father and shared that image with her mother and co-workers. He also used AI to create explicit and incestuous images that placed the faces of minor boys on adult bodies, including young boys related to his victims.

Cops found that Strahler "installed more than 24 AI platforms and more than 100 AI web-based models on his phone," which he used to create hundreds, if not thousands, of non-consensual intimate images (NCII) depicting both women and children.

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Under anti-vaccine Health Secretary Robert F. Kennedy Jr., scientists at the Centers for Disease Control and Prevention have been blocked from publishing a scientifically vetted study finding significant health benefits from this season's COVID-19 vaccines, according to reporting by The Washington Post.

The move adds to longstanding concern among health experts that chaos and political interference under Kennedy—a staunch anti-vaccine activist who has long falsely maligned COVID-19 vaccines—is deeply undermining science at federal agencies and beyond.

CDC scientists and insiders told the Post that the COVID-19 vaccine study went through the agency's standard scientific review process and was slated for publication on March 19 in the agency's Morbidity and Mortality Weekly Report (MMWR). But acting CDC director Jay Bhattacharya blocked the scheduled publication and is holding the study, claiming he has concerns about its methodology.

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